What are nanoparticles?
They are particles which are a 1000 times smaller than the width of a hair.
Nanoparticles come in all shapes and can be made from various materials.
They have a variety of applications, for example, in cancer therapy, where they can produce heat that kills tumor cells.
And how can you make them?
There are different ways of producing these nanoparticles
but these production methods all have their downsides.
We found a SynBio solution:
We designed a biological production method that can be sustainable and cost-effective.
How does it work?
We took DNA from metal-resistant microorganisms,
and transferred it to a model organism for industrial applications: Escherichia coli.
The three proteins that E. coli produced with this DNA can be used to produce nanoparticles in a cell-free system.
The synthesis conditions in this system were optimised both experimentally and by using a model.