Approximately 537 million people around the world suffer from diabetes, while 90% of which are type 2, such disease affects the body’s response or production of insulin, thus limiting one’s capability of controlling their blood sugar levels. Current solutions to this potentially fatal condition are accepted as commonplace in their treatment. However, this inaccessibility to life-saving medicine prompted us to find an alternative to treating symptoms of type 2 diabetes. We constructed a drug screening platform targeting FoxO1, a primary controller for glucose production. And it was successfully screened that compound 355 has the activity of inhibiting the FoxO1 gene. This compound provides a root solution for diabetes, lowering glucose levels in the blood without the need for insulin. We aim for this treatment to be a tablet-pill-based medicine, and more affordable to the general masses.
