Apr
2022
Market data graph
- The skin care efficacy that people mainly concern about are moisturizing, anti-aging, repairing, anti-spot and brightening.
- Based on last year's research and market statistics, we decided to develop a new form of skincare product this year.
Cosmetics store : Watsons's Sales
- We learned that most of the products on the market are single in efficacy. To achieve multiple efficacy, we need to use different skincare products at the same time. Such as Brightening Cream, Brightening Blemish Cream, etc.
- As a consequence, our team intends to develop a multifunctional skincare product.
May
2022
Cosmetics ingredient enterprise :
Cosmetics ingredient enterprise :
Technical Director of Winkey Pharmaceutical R&D Co., Ltd.
- Glutathione(GSH) has relatively mature production methods, but it is easily decomposed, easily oxidized, and not easily stored, so it is difficult to be directly and effectively used in cosmetics.
- Glutathione(GSH) has efficacy of anti-aging, repairing, anti-spot and brightening.
- We design an optogenetic system to control the release of GSH when users use it, so that to provide a new solution for how to maintain the activity of GSH in production, transportation, and storage. After brainstorming, our team finally decided to develop a new form of live bacterial skincare product aimed at solving the problem of direct application of glutathione in cosmetics.
Cosmetics consumers
- We learned that cosmetics consumers (especially young consumers) are very concerned about "skin microbiome".
- Among them, cosmetics consumers mentioned that bacterial lysate has the function of skin microbiome maintenance.
- The engineered bacteria Gluconacetobacter hansenii, modified by 2020 SZPT-CHINA, can produce bacterial lysate when the user use it. It made us more sure that we want to develop live bacterial skincare product.
Dermatologists : Dr. Jingkai Huang and Dr. Jun Huang ,
Southern University of Science and Technology Hospital
- Can glutathione(GSH) be fully absorbed by people's skin?
- Can the product still be used on nonintact skin?
- After certain research, we found that glutathione(GSH) small molecules can be absorbed by the skin. This proves the feasibility of our project agagin. Also, considering the safety when users use our product on nonintact skin raised by the dermatologist, we decided to make further improvements to our product. we will indicate on our product package that" It is not recommended to use the product on nonintact skin ".
Plastic surgeons : Dr. Zhijun Tan, Shenzhen University General Hospital, Dr. Yuru Shang, Southern University of Science and Technology Hospital
- Anti-oxidation is very important to us.
- The common medical aesthetic methods available on the market include photorejuvenation and ultra-pulsed CO2 fractional laser. Although photorejuvenation can solve the problem of pigmentation, it may increases the risk of scarring on the skin.
- We found that anti-oxidation is actually very necessary, and also learned that the antioxidative medical aesthetic methods currently on the market may cause secondary damage to the skin. This prompted us to understand more about the significance of our project.
june
2022
Synthetic biologist :
Synthetic biologist :
Dr. Mingxing Tang
- He suggested removing the LVA tage from pDawn (cl-LVA) to reduce the background expression of the lysis gene and improve the stability of the blue light responsive system.
- Based on the above suggestion, we found through a series of experiments that strains containing the modified plasmids grown to high concentrations under blue light on were able to lyse.
Aug
2022
Live bacterial company :
Live bacterial company :
Yakult factory's technician
- The technician suggested that we should first determine the form of our product, whether it is bacterial liquid or emulsion. In the case of an emulsion, the emulsion formulation should be taken into account, which determines the toughness of the final film.
- After communication, we found that emulsion that is easily accepted by the public and easy to use. We will consider the problem of emulsion formula subsequently.
Biotechnology company :
Dr. Penggao Dai, Technical Director of Shaanxi Lifegen Co., Ltd.
- After we expressed our preliminary idea of using a live bacterial emulsion as the product form, he proposed that freeze-dried powder is also a good product format considering its longer shelf life.
- Considering that the bacterial emulsion is easier to use, we finally decided not to use freeze-dried powder as our product form.
Cosmetics testing company :
Heads of Bode Chuangyan Biotechnology Co., Ltd.
- She suggested that we can adjust the ratio of the thickener, which should be able to improve the toughness of the bacterial cellulose film.
- We learned that zebrafish eggs can be used for antioxidant efficacy testing.
- The product form originally envisaged by our project was an emulsion, but after several preparations and performance experiments, we have improved the emulsion product to a gel product. It also facilitated the progress of our project.
- Considering the welfare of animals, we finally decided to abandon the method of using zebrafish eggs for the detection of antioxidant efficacy, but used a free radical kit (in vitro).
Beauty Salon :
Ms. Lee, Skin Health Specialist at Naturade
- She suggested user usage scenarios should be take into account.
- We got the inspiration for the design of the device from the interview with Ms. Lee, the skin health technician of Naturade Beauty Salon. And we designed a large-scale equipment for the beauty salon. A portable device is designed for other usage scenarios.
