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We develop a live oral cancer vaccine by modifying E.coli to secrete recombinant OMVs containing antigenic proteins that stimulate the immune system to provide cancer immunity. Our aim was specifically to stimulate immune cells in the intestines. To create this level of specificity we incorporated the SulAp optogenetic promoter and a micro-swallowable auto-positioning capsule UVC light source which we trained to recognize that it is in the right location by utilizing a convolutional neural network exposed to a large dataset of endoscopic video footage. And a self-lysis system based on arabinose induction was designed to remove the modified bacteria from the body after completion of OMV secretion.


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