Entrepreneurship
Background
On February 11, 2020, the Director-General of the World Health Organization, Tedros Adhanom Ghebreyesus, announced in Geneva, Switzerland, that name the pneumonia "COVID-19" , which caused by the novel coronavirus. On February 22, 2020, the National Health Commission issued a notification that the English name of "novel coronavirus pneumonia" was revised to "COVID-19". On 11 March 2020, WHO counted that the current COVID-19 pandemic could be called a global pandemic. Nowadays, the global pandemic is scattered in many places of China, and the impact of the novel coronavirus on social order and economic development cannot be neglected.While we are studying how to eliminate the virus, we also need to further strengthen the monitoring of the virus and take timely control measures before the virus spreads in a large area.
The method of monitoring viruses in existing areas is to conduct large-scale nucleic acid testing within the region, but this method also has certain limitations.It is not only consuming a lot of medical resources and medical staff, but also greatly increasing the risk of infection when people gather for nucleic acid testing.
In the early phases of the outbreak, the masses actively cooperated with nucleic acid testing, however, as the front line of the epidemic has lengthened, people's awareness of prevention has gradually declined, many masses have shown a negative attitude, who expressed reluctance to cooperate with the current large-scale scheduled nucleic acid testing. There may even be a phenomenon of substitution testing or falsely claiming to have had a nucleic acid test. Such a situation could lead to a large-scale outbreak of localized outbreaks.In order to avoid the occurrence of the above, we suggest that through indirect data testing, Statistics will be carried out and reported by the epidemic prevention department, instead of large-scale nucleic acid detection.
In the early phases of the outbreak, the masses actively cooperated with nucleic acid testing, however, as the front line of the epidemic has lengthened, people's awareness of prevention has gradually declined, many masses have shown a negative attitude, who expressed reluctance to cooperate with the current large-scale scheduled nucleic acid testing. There may even be a phenomenon of substitution testing or falsely claiming to have had a nucleic acid test. Such a situation could lead to a large-scale outbreak of localized outbreaks.In order to avoid the occurrence of the above, we suggest that through indirect data testing, Statistics will be carried out and reported by the epidemic prevention department, instead of large-scale nucleic acid detection.
Innovation
Current testing methods/competitors
Nucleic acid detection is currently the most reliable means of screening and confirming whether humans are infected with the novel coronavirus (2019-nCoV), However, with the normalization of COVID-19, there is a need for faster and more convenient means of large-scale testing instead of frequent nucleic acid testing. Antigen detection has been added to Coronavirus detection, but as the antigen detection is similar to the principle of nucleic acid detection, and the sampling requirements are more complex, it can only be used as an important supplement to nucleic acid detection which cannot be replaced. Medical detection dogs have also become "weapons" for COVID-19 detection[1],which are a kind of sniffer dogs, mainly through the sensitive sense of smell of dogs to find potential viruses in humans. however, due to the difficulty of dog breeding, it cannot be widely popularized ,although this method can be tested on a large scale. Quality Control Circle(QCC) refers to a group of people with similar work natures spontaneously formed by a group, selecting quality improvement themes, using various quality control techniques and team strength and continuous quality improvement activities at the work site based on the application of Quality Control Circles[2]. The QCC has shown excellent results in clinical quality management. However, although the QCC has a Positive impact on shortening the waiting time for nucleic acid detection of the novel coronavirus, the waiting time before sampling of subjects has become significantly shorter, and it still cannot settle the core matter of "large-scale detection".
Different people can see the project from different perspectives and it is not enough to just discuss it within the team. Therefore we tried to contact experts or practitioners from various fields. We took down as many of their suggestions as possible, whether they were complimentary or critical of us. After filtering out the valid suggestions, the gaps in our project were improved and its positive and negative impact on the future was analysed. We have followed this rule throughout the course of our human social practice. This allows us to better facilitate the progress of our projects.
Our team has proposed a new solution for screening new coronavirus (2019 nCoV). We want to bypass large-scale nucleic acid testing, and the epidemic prevention department will directly detect and report it. We have designed a device that can detect new coronavirus in sewage, which can detect and report possible confirmed patients or asymptomatic infected persons at the initial stage of the epidemic.
Our Products
We have designed a device that can detect the novel coronavirus in sewage- Jiang Ziya 2.0 (Angler 2.0), which can detect the presence and spread of the virus in the earliest stages of an outbreak and report the number and conditions of possible confirmed or asymptomatic infections. In this way, the spread of the virus can be effectively and quickly monitored, and the novel coronavirus can be controlled in a small and controllable range in the fastest possible time. Effective early warning mechanisms remain the most needed technical means until mass vaccination is available, and certain epidemic pathogens which are the waterborne infectious diseases, such as Vibrio cholerae and poliovirus can be transmitted from contaminated water sources. After investigation, it was found that the novel coronavirus can remain in the feces or urine of infected people and maintain a certain amount of activity for a long time. Thus, we can qualitatively or quantitatively deduce the health status of residents in the sewage collection area by quantitatively analyzing the chemical or biological markers in the sewage. Thus, we can quantitative analysis of chemical or biological markers in wastewater to qualitatively and quantitatively deduce the health status of residents in the sewage collection area.
Figure 1 Ziya Jiang 2.0（3D Modeling Diagram）
Key Technologies
First, we use mathematical modeling to predict whether there is a novel coronavirus in the sewer, and if it is found, the possible concentration of the novel coronavirus will be measured as soon as possible. The FAFU team built a hardware that can first initially purify the water quality, exclude the interference of some large substances, and then collect the possible virus, and react with the respiratory receptor proteins with stronger binding ability that we screened and detection, finally we make qualitative judgments through fluorescence signals. The detection line of this immunosensor can reach micrograms per milliliter, allowing the detection of viruses in sewage.Indirect real-time monitoring of residential users’ domestic water can be used to determine whether there exist a suspicious novel coronavirus and other water-borne viruses. This method can afford timely and effective information to the Ministry of Health and relevant epidemic prevention departments to prevent the spread of the novel coronavirus and other types of infectious diseases.
Conducted social survey/feasibility analysis
According to the survey, since the outbreak of the epidemic, factories in various industries have faced the matter of labor shortages: in order to response to the government's demand for control of the flow of people during the epidemic, the arrangement of factory workers has changed significantly, factory workers have been reduced from 285 workers to 118 workers, and even fewer after the epidemic. Among them, the reasons are the difficulty of recruiting workers after the epidemic, and there are also layoffs due to the decline in the economic benefits of enterprises. In addition to the issue of labor, the cost of raw materials and logistics has also multiplied greatly. In 2021, the price of raw materials in the stone industry in Quanzhou City increased by 12-18% compared with that in 2019, and the logistics cost also increased by 20-23%. Under the influence of various external factors, the actual turnover of enterprises in 2021 is 28.6% lower than that in 2019.
In addition to economic problems, there are also the health problems of factory workers. Once a person is infected or conceals the history of travel and residence, the factory will face a huge blow. It can be seen that a more direct and fast detection technology is particularly crucial.
Business plan
Market analysis
PEST
SWOT
Market pain points
The current epidemic prevention and control measure is generally to carry out large-scale nucleic acid detection, but this method has certain limitations. For example, the current nucleic acid detection needs to be tested at a certain site. In the process of waiting for nucleic acid detection, people will not keep a one-meter distance or wear masks, which greatly increases the risk of virus spread. This has created hidden dangers for local outbreaks.
Business Model
Operation mode.
The equipment we designed to detect the novel coronavirus in sewage can be installed in the sewer pipes of residential buildings, school canteens and dormitories, and factory staff dormitories. Therefore, we sell products to units with concentrated personnel and responsibility for epidemic prevention and control, such as communities, factories, schools, etc. In the early stage of the epidemic, confirmed patients or even asymptomatic infections were identified through this device, and they were directly tested and reported to the epidemic prevention department, rather than large-scale nucleic acid testing, which could shorten the time for testing and reporting, thus improve the accuracy of testing. This provides an efficient, convenient and safe new nucleic acid detection mode for epidemic prevention units, which greatly reduces the large-scale infection that may be caused by missed inspections, substitute detection, omissions, and concealment.
Profit model
Once a large-scale social infection occurs in communities, factories, schools and other gathering places, it will pose a very serious threat and impact on the lives and health of the broad masses and regional economic development. We intend to make a profit with the community street office, the factory management department, and the epidemic prevention office of school as the customer base, with the COVID-19 rapid screening component as the core product, supplemented by technical support and virus detection and alarm system.
As the macro-controllers, managers, and epidemic prevention policy makers of epidemic prevention and control, the government will have a direct impact on the market, business performance and preferential policies enjoyed by our products.
We propose to strengthen the local government's understanding of the status, resource allocation, value recognition and importance of the project through close cooperation with the epidemic prevention of government, economy and community management workers, and further enhance the profitability of the project.
Finance
Revenue forecast
Team status
The team business includes sales of Ziya Jiang 2.0, maintenance services of Ziya Jiang 2.0, and sales of derivatives. Since the market has not been expanded at the initial stage of entrepreneurship, and the venture capital is limited, the sales of Ziya Jiang 2.0 and the maintenance service of Ziya Jiang 2.0 are the main businesses of the team at the initial stage of operation, so various financial statements are budgeted by these two businesses first.
Cost budget
Team status
Ziya Jiang 2.0 Cost Budget
Table 1 Jiang Taigong 2.0/piece Cost components
| Name | Amount | RMB |
| 5 inch cartridge box | 2 | 26 |
| 5 inch PP filter element | 2 | 10 |
| 2 point quick connection straight (outer wire) | 3 | 12 |
| 2-point quick bend (external wire) | 4 | 16 |
| 50 g self-priming pump | 1 | 128 |
| DC12v90 degree solenoid water valve | 9 | 97 |
| DC12V straight solenoid water valve | 1 | 36 |
| 2mmCustom size glass | 5 | 50 |
| Miniature stepping motor | 1 | 71 |
| 1 meterLED light strip | 1 | 10 |
| 2 point PE water pipe 5 meters | 1 | 5 |
| ST3.5*30 self tapping screw | 6 | 5 |
| ST3.5*19 self tapping screw | 4 | 5 |
| ST3.5*13 self-tapping screws | 4 | 4 |
| ST3.5*9.5 self tapping screw | 4 | 4 |
| ST2.2*6.5 self tapping screw | 12 | 4 |
| Thrust ball bearing 51103 | 1 | 3 |
| 3D printed shell | 1 | 200 |
| Circuit board | 1 | 300 |
Ziya Jiang 2.0 of the team is expected to pilot in two factories in Quanzhou at the end of October. After the completion of the pilot project, the commissioning will be carried out according to the actual situation, and the traffic garden community in Chengxiang District, Putian City will be initially put into use in December 2022. The specific cooperation has been contacted with the corresponding property company and neighborhood committee. We will increase the price of 350 RMB/piece on the basis of the cost price for sales, and give away one year of maintenance services.
Considering the operation and marketing costs of the team, Ziya Jiang 2.0 will sell at 1486 RMB each to ensure profitability.
Maintenance cost of Jiang Taigong 2.0
Later, maintenance inspection will be carried out once a quarter to ensure the normal operation of the device. The maintenance inspection will be carried out by the core members. The maintenance inspection needs to prepare reagents. The cost is about 20 RMB/piece/time, and the external bid price is 50 RMB/piece/time.
Sales volume forecast
2022 Sales volume forecast
Since the market has not been expanded at the initial stage of entrepreneurship and the venture capital is limited, the sales of Ziya Jiang 2.0 and the maintenance services of Ziya Jiang 2.0 are the main businesses of the team at the initial stage of operation. In 2022, the main businesses will be concentrated in Jiaotong Garden Community, Chengxiang District, Putian City, and the installation of Ziya Jiang 2.0 will start at the end of the year. Therefore, the sales volume in 2022 will depend on the number of orders of the community.
According to the current negotiations with the property company and the neighborhood committee corresponding to the community, we will sell 45 Ziya Jiang 2.0. It is estimated that the turnover will be 60120 RMB, and the net profit will be about 11500 RMB after deducting the experimental expenses, labor costs, transportation costs and product costs.
2023 Sales volume forecast
After fully undertaking the project of Putian Jiaotong Garden Community in 2022, the team will continue to deepen cooperation with the team and install Ziya Jiang 2.0 at all sewage outlets of the community.
We will also expand our business and provide services such as Ziya Jiang 2.0 sales, Ziya Jiang 2.0 maintenance and inspection in at least three communities in Cangshan District, Fuzhou City and Quangang District, Quanzhou City. It is estimated that the turnover will be 288500 RMB in 2023, and the net profit will be 58600 RMB after deducting the experiment expense, labor expense, transportation expense, maintenance expense and product cost.
2024 Sales volume forecast
The team will fully undertake the business of at least 4 communities in Putian Jiaotong Garden Community, Cangshan District, Fuzhou City and Quanzhou Quangang District, and will fully explore the market in Fujian. We have carried out sales, maintenance and inspection of Ziya Jiang 2.0 in many places in Fujian. At the same time, the research and development of Ziya Jiang 2.0 derivatives will also carry out certain marketing of products. It is estimated that the turnover will be 895200 RMB in 2024, and the net profit will be 157800 RMB after deducting the experiment expense, labor expense, transportation expense, maintenance expense, marketing expense and product cost.
Table 2 2022-2024 Business Scope and Revenue Forecast
Year |
Region |
Turnover |
Total project cost |
Total profit of the project |
2022 |
Putian City |
60,120 |
48,620 |
11,500 |
2023 |
Putian City, Fuzhou City, Quanzhou City |
288,500 |
229,900 |
58,600 |
2024 |
All over Fujian |
895,200 |
737,400 |
157,800 |
Figure 2 2022-2024 Revenue and Revenue Forecast
Source of funds
The company intends to register a total of 1 million RMB, 800,000 RMB for the company's founders to initiate capital investment and technology investment (project leader Jiao Sibo holds 52%, Ke Weiyue and other founders hold 28%), financing transfer of 200,000 RMB.
The project has a high degree of cooperation with the epidemic prevention department of government, and plans to negotiate with the government to obtain more subsidy funds.
| Source of equity capital | Company founder investment | ||||
| Capital shares | Capital shares |
Capital shares |
Capital shares |
Capital shares |
|
Name of shareholder |
Sibo Jiao |
Weiyue Ke |
Chunyu Jiang |
Yining Wang |
Qinyu Chen |
| Investment amount | 520,000RMB |
50,000RMB |
50,000RMB |
50,000RMB |
50,000RMB |
Investments ratio |
52% |
5% |
5% |
5% |
5% |
| Source of equity | Company founder investment | equity trading | |||
| Technology shares | Technology shares |
Technology shares |
Technology shares |
||
Name of shareholder |
Zhonglin Cao |
Yuheng Chen |
Weijie Guo |
Chenjie Liu |
investment company |
Financing and investment
In the early stage of development, we plans to release 20% of the equity and raise 200,000 RMB; the project funds will be used for product research and development, equipment production, land leasing, and operations.
Risk Analysis and Countermeasures
Policy risks and Countermeasures:
The direction of our project development space is closely related to the national macroeconomic policy, and the introduction of national policies or standards will have a extremely impact on the service of the project. If the relevant national policies change, we will not be able to enjoy the above-mentioned relevant market and preferential policies, which will have a greater effect on our local business performance. In addition, the local government’s awareness of the status, resource allocation, value awareness, and importance of this project will bring certain risks to the project construction.
Countermeasures or measures
①In strict accordance with the direction of national policies, and make full use of the current favorable macro environment, strengthen communication with the government, actively pay attention to the relevant policy trends and trends of the country, and make a response plan for policy changes in advance.
②Formulate a strategic development plan for new fields, and consider the follow-up ability of self-reliance and self-development to adapt to changes in national policies, actively handle the relationship with customers and relevant departments, and play a positive role in the formulation of policies and the behavior of customers.
③Improve the industry entry threshold using the characteristics of the current market competitors are scattered and can not fully solve the market pain points, At the same time, we should do a good job of nurturing and developing this emerging market to offset the possible negative impact of changes in relevant policies.
Technical risks and countermeasures:
As an enterprise that started scientific and technological innovation, new products need to go through the process from development to industrial production and recognition by the market. There are more intermediate links, larger capital investment, longer cycle, and there exist a risk of product development failure.
Countermeasures or measures
①Strengthen the collection and collation of technical and market information in order to avoid blindness in product research and development;
②Strengthen technical cooperation with universities and other scientific research institutions in a targeted manner, establish a technical support system jointly developed by industry, education and research in the form of strategic alliances, and shorten the time for research and development of new and strong technology to improve their success rate.
Enterprise management risks and countermeasures:
Due to the relatively young age structure of our team members, lack of experience in management and operation, There will be an over-reliance on the core team member in the early stage of operation. And as the company expands, it will lead to a serious shortage of managers and technical service personnel.
Countermeasures or measures
Strengthen the supervision of the management district team, make full use of resources, actively use the advisory group and hire relevant independent directors to improve the scientific and accurate decision-making. At the same time, external managers with rich experience in the market and the operation of the company are openly recruited from the talent market. Strengthen the systematic training of employees, and formulate completed career planning and job promotion routes for employees. From the grassroots, a part of the staff with strong business ability and high loyalty is selected to focus on training, as a reserve management and technical force for the company to expand its scale.
Market competition risks and countermeasures:
With the normalization of the management of the epidemic and the new challenges that may arise in the future, more and more enterprises at home and abroad are engaged in rapid virus inspection, so it may bring greater competition of our team in the future.
Countermeasures or measures.
We not only need to maintain existing customers, but also rely on the unique advantages of our technology and service delivery to quickly reach more markets, occupy more market share, and expand to other markets than the existing business as much as possible. At the same time, increase the popularity of our team; And according to the market sales of the product to adopt a flexible marketing strategy to ensure the advantages of the product / service; Providing attractive and more perfect after-sales service system and daily care of each household, in order to improve the comprehensive competitiveness of our products in the market.
Team organization
Company Structure
A reasonable company structure can help the team to complete the work more efficiently and organizationally, although the project team members do not change their original intentions and clear the core technology of the project, limited to experience and expertise, in some specific positions we still need professional people to perform. we initially divided our company into the following departments PMT、ADMIN&TECHNICAL、SALES、ACCOUNTS、DISTRIBUTION、R&D、LEGAL、HR
Social Benefits
With the improvement and popularization of sewage detection system, a sewage epidemic monitoring network is formed in various areas, which greatly eases the relationship between ordinary residents and nucleic acid detectors and nucleic acid monitoring points with convenience, accuracy, rigor and safety, and through the liquidity monitoring of the areas with the most dense elements of life at the sewer mouth, the nucleic acid detection in a large area or in a short period of time is checked and fills in the gaps, and the virus is accurately screened with the accuracy of a single virus monitoring, and the infectious disease status in residential areas is strictly screened.
In order to timely update and select the optimal binding protein of the epidemic virus that needs to be monitored, this project will provide employment opportunities for some high-end scientific researchers, As soon as a wave of infectious diseases may form a wave, the binding protein is screened to achieve rapid and accurate monitoring and protection in the early stage of the outbreak. The way that wastewater detection systems use competition to bind protein affinity to monitor viruses also has some implications for the pharmaceutical industry, that is to say,using the biosynthesis to make protein drugs, the mass production of synthetic protein fragments as competitive binding fragments in engineered bacteria, and the preemption of viral spike proteins to kill viral toxicity and reduce the harm of viruses to human beings.
Our later goal is to cooperation with the government and achieve a large-scale sewage monitor installation, which is a prerequisite for extensive screening for the virus.Through the flow of domestic wastewater at the sewage outlet, it is possible to achieve multiple inspections and accurate screening, reduce the frequency of nucleic acid testing in the form of multiple insurance, thereby saving public health resources, while reducing mandatory intervention in the lives of residents, and alleviating public sentiment and reducing the risk of infection caused by aggregation in the context of the normalization of the prevention and control of the novel coronavirus now and in the future in which large-scale infectious diseases may break out. The team will strictly control the quality control of the sewage monitoring system, and constantly update and iterate on the original basis, give optimized detection proteins for infectious viruses that have broken out in the past, and timely update the detection protein library for new infectious diseases that may appear in the future, avoid multiple updates in hardware requirements, form a flexible and lasting sewage monitoring system, improve the support scientific research guarantee of social health, and strive to achieve timely response and efficient monitoring.
Future
After many tests and field inspections of sewage treatment plants, this project has efficient screening capabilities for various waterborne infectious diseases, and can complete the effective analysis and quantification of labeled viruses in sewage in a short period of time, which can further replace large-scale nucleic acid detection. It is expected to achieve early implementation of projects in the epidemic area, and provide reliable health conditions for epidemic prevention departments in the early stage of the epidemic, so as to carry out efficient epidemic prevention and control. Cooperating with the government and relevant health departments to do a good job in mapping out various regions, while meeting the standards of epidemic prevention and control, we should also pay attention to the invasion of other types of waterborne infectious diseases, and carry out isolation measures and medical protection as soon as possible when other waterborne infectious diseases are monitored.
In the future, we will further improve the accuracy of the project and increase the scope of monitoring, so as to achieve indirect statistics on the health of people in the precinct by monitoring the virus content and composition of sewage in real time. , It further provides safety and security for the people in the community through the real-time monitoring of various water-borne infectious diseases in the community. In the meanwhile, it can also provide real-time monitoring for the Health Department and the Environmental Protection Bureau, and offer favorable data and information for various indicators and favorable standards that exceed the standard. We will cooperate with the hospital in the treatment of medical wastewater and conduct comprehensive testing, including the hospital's medical wastewater generation, centralized treatment of medical wastewater and final discharge. Do our best to achieve effective monitoring while treating medical wastewater in situ in hospitals, so that the content of various other pollutants in hospital medical water that meets discharge standards is reduced as much as possible. And finally we should strengthen risk control awareness, target monitoring and treatment of labeled viruses and pollutants.
Quote
[1] Wang, Bingqian (ed.). Medical detection dogs also become the new crown detection "weapons" [J]. China Working Dog Industry,2021(3):11-12
[2] Wang, C. C., Huang, Y. H., Liu, Y., Huang, S. H., Li, Y., and Wang, L. Z.. Study on the waiting time reduction strategy of new coronavirus nucleic acid test-application based on quality control circle[J]. Journal of Guangdong Medical University,2022,40(2):211-215
