Levels of the military-grade explosive RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine) exceeding the EPA’s established limits have been detected at the Anones Lagoon in Vieques, Puerto Rico. RDX has shown adverse effects to humans, flora, and fauna, thus posing a risk to the Vieques ecosystem and its inhabitants. We propose a biosensing, cell-signaling module inducible by presence of RDX and coupled to a biodegradation module via the quorum-sensing signal molecule, AHL. We identified two possible biosensing elements in previous works: a transcriptional fusion of two promoters from nitric oxide (NO) detoxification-associated genes, and a synthetic aptamer riboswitch with high affinity for RDX. For the biodegradation module, we identified a P450 cytochrome and reductase duo, XplA/XplB, isolated from bacterial isolates with RDX-degrading capabilities. Unfortunately, we were unable to complete the wetlab work due to an unanticipated meteorological event that left the island without power. We hereby demonstrate our proof of concept and future works ahead.