Recombinant spider silk gels as bio-ink for 3D printing of artificial skin

Skin lesions caused by burns and trauma are very common in clinical practice. However, due to the limitations of such factors as large area of skin graft, long treatment period and high price, it is not enough to meet the needs of patients. In recent years, the development of 3D biological printing has provided a new idea for skin transplantation and brought dawn to patients with skin diseases and skin related industries. In the process of preparing biological ink for 3D printing, materials with good printing adaptability and cell compatibility is the biggest bottleneck at present. As recombinant spider silk protein has low immunogenicity, good cell compatibility and physical crosslinking ability, we set to construct a composite gel based on spider silk bio-ink, and evaluate its potential as a new biomaterials for 3D artificial skin or other scaffold printing or as new wound dressings.