Background
In 2020, malaria caused an estimated 241 million clinical episodes, and 627,000 deaths. An estimated 95% of deaths in 2020 were in the WHO African Region. According to WHO Malaria report 2022, in 2020,four African countries accounted for just over half of all malaria deaths worldwide: Nigeria (31.9%), the Democratic Republic of the Congo (13.2%), United Republic of Tanzania (4.1%) and Mozambique (3.8%).
Illustration
Worldwide Malaria Analysis
Our Solution
- Azadirachtin, a limonoid isolated from the neem tree has attracted considerable interest due to its excellent performance in mosquito repelling and other insect control abilities
- In this study, an 2,3-oxidosqualene cylase, AiOSC1and a cytochrome oxidase, AiCYP71CD2 have been identified as involved to be azadirachtin biosynthesis in neem. They will be expressed in yeast (saccharomyces cerevisiae DI-3 strain).
- These two enzymes produce dihydroniloticin an intermediate used in the synthetic production of azadirachtin
- The synthesized Azadiractin will be blended with either limonene, strawberry, vanilla or lemon grass to improve the odor, and the blend incorporated into a solar based diffuser