Header Image

What is PCOS?

Polycystic Ovary Syndrome (PCOS) is a condition in which multiple cysts form in ovaries due to unknown factors. Research suggests it is caused due to a combination of hormonal, genetic, and metabolic factors.

Symptoms: Acne, Hirsutism, Oligomenorrhea, Amenorrhea, Weight gain, and Infertility

The syndrome is also called the Stein-Leventhal Syndrome, after researchers who first identified it, Irfing Freiler Stein Sr. and Michael Leventhal

Uterus decorated with Flowers Uterus decorated with Flowers

What is PCOS?

Polycystic Ovarian Syndrome (PCOS) is a condition in which multiple cysts form in ovaries due to unknown factors. Research suggests it is caused due to a combination of hormonal, genetic, and metabolic factors.

Symptoms: Acne, Hirsutism, Oligomenorrhea, Amenorrhea, Weight gain, and Infertility

The syndrome is also called the Stein-Leventhal Syndrome, after researchers who first identified it, Irving Freiler Stein Sr. and Michael Leventhal

Uterus decorated with Flowers Uterus decorated with Flowers

Fig 1. World Health Organisation (WHO) reveals that nearly 3.4% of people have PCOS globally.

Fig 2. In India 2 in 10 women have PCOS.

Fig 3. An estimated 70% of PCOS cases remain undiagnosed.

Current Diagnostics

Blood test

Selected hormones in the blood are tested. However, these hormones aren’t specific to the syndrome and can show fluctuating levels in the case of other metabolic disorders, which can lead to misdiagnosis

Ultrasound Scan

Ultrasound scan inspects the morphological anatomy of the ovary. Screening for cysts and the size of each ovary is done to look for abnormalities. But ultrasound scans cannot distinguish between ovarian tumours and cysts, leading to misdiagnosis. Also, the lack of accessibility of Ultrasound scans hinders the diagnosis in rural areas

Pelvic examinations

A medical professional examines the pelvic and the medical history of the person including mapping the fluctuations in menstrual cycles. Based on this a diagnosis can be made. Since symptoms of PCOS are nonspecific, they can vary from person to person. Additionally, there are issues of privacy with these examination methods

.

The Idea

To tackle the issues with the current diagnostic methods, we propose “AptaSteles,” a novel aptamer-based diagnostic kit. The kit diagnoses based on a range of biomolecules in the blood associated with PCOS symptoms. Specific aptamers detect these molecules and produce a fluorescent signal that is converted to a digital readout. The aptamers are integrated in a hardware device based on microfluidics. Thus, we take a step forward towards a private and hassle free PCOS diagnosis.

Discover our project design on how we tackle the issue of PCOS diagnosis

PROJECT

Visit our wetlab to know how we tried verifying our approach experimentally.

WET LAB

Check out our drylab to discover how in-silico analysis assisted our project

DRY LAB

Find out how human practices helped us understand the impact of our kit

HUMAN PRACTICES

Check out to explore the journey of our kit.

HARDWARE

Do watch our Promo Video below

Footer with Sponsors