Androgenetic alopecia

Androgenetic Alopecia is the most prevalent type of hair loss, affecting around half of all males over the age of 50 and roughly half of all women over the age of 65. Younger men and women can be affected by androgenetic alopecia. Androgenetic alopecia is most likely caused by a combination of genetic and environmental causes.

RNA interference (RNAi)

RNA interference (RNAi) is a conserved biological response to double-stranded RNA that provides resistance to both endogenous parasite and exogenous pathogenic nucleic acids and regulates the expression of protein-coding genes. A gene is silenced as a result of RNA degradation into small RNAs (siRNAs and microRNAs) that activate ribonucleases to target homologous mRNA.

Small extracellular vesicles (sEVs)

Small extracellular vesicles (sEVs) are cell-created protein, lipid, or nucleic acid delivery systems that also serve as a form of extracellular communication. sEVs are now at the forefront of research with various physiologic and pathological activities. sEVs are considered to be a good biocompatible delivery system for RNAi technique.

NJU-China's project

NJU-China iGEM team's goal is to develop a AGA drug with minimal side effects, stable results, and ease of use. On the one hand, we applied the RNAi technique and mRNA embedding elements to regulate gene expression particularly. On the other hand, we used sEV and microneedles to carry and deliver siRNA and mRNA to follicle cells.

Quick Link:

Project Human Practices Model Achievements

Androgenetic alopecia

RNA interference (RNAi)

Small extracellular vesicles (sEVs)

NJU-China's project

Quick Link:

Contact Us