Encapsulin-Facilitated Antimicrobial Peptide Production

Antibiotic resistance is a growing crisis in which existing antibiotics lose effectiveness against certain pathogens

Antimicrobial peptides (AMPs) are a rich source of novel antibiotics with the potential to target antibiotic-resistant bacteria

Synthesizing proteins (such as AMPs) using recombinant gene expression is a fast, convenient, and inexpensive method

Expressing AMPs in bacteria, however, is challenging given they target the very bacteria that's producing them

Our project aims to solve this issue by sequestering the AMPs within encapsulin nanocompartments as they are produced


iGEM Gold Medal