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What Do Pathogens, Traffic Emissions and Dying Forests Have in Common?

All of these problems could be tackled with monoterpenoids, a greatly underestimated class of compounds...

Monoterpenoid Applications Are Vast

Monoterpenoids can be cancer drugs, biofuels or pesticides and even fragrances or flavourings!

Unfortunately, the Potential of Monoterpenoids Is Not Yet Exploited

For now, most monoterpenoids are extracted from plants in an energy-intensive and environmentally harmful process. This production method is neither efficient nor sustainable ...

Introducing MonChassis:
A Novel Monoterpenoid Production Platform

Reinventing Yeasts
as Factories for Monoterpenoids

To establish a powerful pathway for the efficient production of monoterpenoid precursors, we metabolically engineered both Saccharomyces cerevisiae and Yarrowia lipolytica. We cloned a total of 108 different constructs and successfully introduced 16 different genes into our yeast strains.

Yeasts’ Best Friend: BREES

The precursors are easily and efficiently converted into a variety of monoterpenoids by our cell-free, electrically-driven system: BREES – short for BioReactor for Enzymatic ElectroSynthesis

The Impact of Monoterpenoids
– Exemplified by Verbenone

To display the functionality of MonChassis we produced the monoterpenoid verbenone. This repellent pheromone is capable of containing infestations of forests by the bark beetle, a rapidly expanding threat to our woodland ecosystems.