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Abstract
Colourectal is a diagnostic tool for colorectal cancer (CRC). We are developing a probiotic self-test to allow for simple screening of CRC. We are achieving this by modifying E. coli to bind tumour cells, detect two distinct cancer biomarkers, and secreting a coloured protein in the faeces. Lactate serves as the first biomarker, which is detected by a CRISPR-Cas based threshold circuit, only giving a signal at significantly elevated lactate levels. The second biomarker, MMP-9, activates the colour of our coloured protein. Additionally, we aim to create a biosafety circuit to limit E. coli to the colon by creating a dependence on temperature and mucin.
The Statistics
The survival rate of colorectal cancer is
91% when caught early and
14% when metastastised.
Colorectal cancer is the third largest cancer in the world
Colorectal cancer is the second most deadly cancer in the world
Current Treatment
Blablabla bad treatment option, can do so much better wowsies
Our Solution
Our Solution lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco lab
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