PARTS
Description: Bombolitin is a naturally occurring peptide that can be found as a component within bumblebee venom. The peptide itself is a positively charged molecule, allowing it to interact with negatively charged cell membranes of bacterial organisms. This interaction will cause cell lysis in most bacterial cells, including both gram negative and positive bacterias. This quality of the peptide has allowed it to be considered an antimicrobial peptide, making it an attractive molecule for agricultural applications. The sequence of bombolitin is LNLKKILGKIGVMLS. Its net charge is +4, hydrophobic ratio is 50%, and GRAVY Index 0.58.
Description: In order to increase the hydrophobicity of the modified bombolitin, three additional amino acids, phenylalanine, leucine, and tryptophan, were added to the end of the sequence. The sequence is LNLKKILGKIGVMLSHLNLLL. Its net charge is +3.25, hydrophobic ratio is 55%, and GRAVY Index is 0.91.
Description: In order to increase the hydrophobicity of the modified bombolitin, three additional amino acids, WWW, were added to the end of the sequence. The sequence is LNLKKILGKIGVMLSHLNWWW. Its net charge is +3.25, hydrophobic ratio is 55%, and GRAVY Index is 0.91.
Description: In order to increase hydrophobicity and efficiency of the bombolitin, three additional FFF amino acids were added to the end of the strand. This resulted in the sequence to become, LNLKKILGKIGVMLSHLNFFF, with the charge of the molecule to be +3.25, hydrophobicity ratio to become 57% and GRAVY index of 0.90.
