Resensitizing Pseudomonas aeruginosa for better antibiotic treatment.
Resensitizing Pseudomonas aeruginosa for better antibiotic treatment.
Antibiotic resistance is the ability bacteria develop to defeat drugs that are used to kill them.
In recent years, there has been a rise of resistant bacterial populations due to an excessive and incorrect use of antibiotics.
This poses serious public health concerns, as this limits our options to treat life-threatening infections.
According to the World Health Organization,
antibiotic resistance will be the cause of
According to the World Health Organization,
antibiotic resistance will be the cause of
This issue disproportionately affects developing countries such as Mexico, where lack of health infrastructure facilitates the spread of nosocomial infections.
Prescribed antibiotics are not efficiently prescribed and even unnecessary
Pseudomonas aeruginosa is resistent to meropenem
To develop one new antibiotic
is the second most frequent type of acquired infection in Mexican hospitals.
Caused by Pseudomonas aeruginosa , its high rate of antibiotic resistance makes treatment extremely complicated.
The most straightforward answer: resensitize these bacteria, as well as silencing vital genes and virulence factors to ensure its erradication, targeting the antibiotics they have become resistant, all of this using:
First, sRNAs are computationally designed with our program sRNA Designer.
The selected sRNA is coded into a plasmid, which is delivered via modified M13 bacteriophages that are encapsulated in liposomes.
This phage-liposome complex is nebulized, inhibiting the antibiotic resistance genes on the target bacteria population
Finally, the bacteria is resensitized to conventional antibiotics and erradicated by the silencing of vital genes.