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In the body of a cancer patient, tumor cells are like those moles constantly popping out of a whack-a-mole machine. They grow and reproduce, and along the way, they mutate and evolve into completely different individuals. This poses a difficult problem for current cancer treatment.
The traditional cellular immune threapy for cancer is CAR-T therapy, which involves loading T cells with a CAR to recognize tumor cells. However, this CAR is like a little hammer, it can only hit one mole at a time, that is, it can only recognize one tumor antigen at a time. It is powerless against various mutated tumour cells.
How can we effectively address such a wide variety of tumor cells? This year, we NMU-China successfully designed a giant hammer---CAR Library, through antibody library technology. The CAR library can recognize almost any tumor antigen, like a giant hammer which can hit all the moles simultaneously.
And then we load the NK cells with this giant hammer. Armed with this giant hammer, the NK cells, by some miracle, can recognize the antigens of all those mutated tumor cells and kill them quickly. Giving the tumor cells nowhere to run.
No matter which hole the moles will emerge from, no matter how the tumor cells mutate, NK cells equipped with such a giant hammer will definitely find them and kill them. CAR-NK will definitely win.
