| MiamiU| MiamiU
We are Miami University's iGEM team and our project SynPhage aims to create a modular biological system for targeting antibacterial resistance (AR). This phenomenon takes a devastating toll on public health that only worsens with each generation. Our proof-of-concept design involves sortase-mediated engineering of bacteriophages to target the receptors of pathogenic bacteria and deliver CRISPR-Cas for silencing AR expression. Receptor recognition is directed by post translational attachment of a nanobody via sortase enzymatic activity. These two levels of selectivity contribute towards development of highly programmable therapeutics.
